InnateDB Protein
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IDBP-238531.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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DOK5
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Protein Name
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docking protein 5
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000379270
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InnateDB Gene
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IDBG-81690 (DOK5)
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Protein Structure
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Function |
DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK5 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway. Putative link with downstream effectors of RET in neuronal differentiation.
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Subcellular Localization |
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Disease Associations |
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Tissue Specificity |
Highest expression in skeletal muscle, lower in brain, heart and kidney. Also detected in activated peripheral blood T-lymphocytes. {ECO:0000269PubMed:12595900, ECO:0000269PubMed:12730241}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
6
[view]
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Protein-Protein |
6
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
Accession |
GO Term |
GO:0005158
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insulin receptor binding
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR002404
Insulin receptor substrate-1, PTB
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PFAM |
PF02174
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PRINTS |
PR00628
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PIRSF |
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SMART |
SM00310
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TIGRFAMs |
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Modification |
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SwissProt |
Q9P104
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PhosphoSite |
PhosphoSite-Q9P104
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
55816
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UniGene |
Hs.656582
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RefSeq |
NP_808874
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HUGO |
HGNC:16173
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OMIM |
608334
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CCDS |
CCDS13447
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HPRD |
16317
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IMGT |
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EMBL |
AF132732
AF466368
AL050069
AL118501
AL162292
BC008992
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GenPept |
AAF66443
AAH08992
AAL74194
CAB43255
CAI16465
CAI19415
CAI19416
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