InnateDB Protein
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IDBP-238594.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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RRM2B
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Protein Name
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ribonucleotide reductase M2 B (TP53 inducible)
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000379248
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InnateDB Gene
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IDBG-31119 (RRM2B)
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Protein Structure
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Function |
Plays a pivotal role in cell survival by repairing damaged DNA in a p53/TP53-dependent manner. Supplies deoxyribonucleotides for DNA repair in cells arrested at G1 or G2. Contains an iron-tyrosyl free radical center required for catalysis. Forms an active ribonucleotide reductase (RNR) complex with RRM1 which is expressed both in resting and proliferating cells in response to DNA damage. {ECO:0000269PubMed:10716435, ECO:0000269PubMed:11517226, ECO:0000269PubMed:11719458}.
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Subcellular Localization |
Cytoplasm. Nucleus. Note=Translocates from cytoplasm to nucleus in response to DNA damage.
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Disease Associations |
Mitochondrial DNA depletion syndrome 8A (MTDPS8A) [MIM:612075]: A disorder due to mitochondrial dysfunction characterized by various combinations of neonatal hypotonia, neurological deterioration, respiratory distress, lactic acidosis, and renal tubulopathy. {ECO:0000269PubMed:17486094, ECO:0000269PubMed:18504129}. Note=The disease is caused by mutations affecting the gene represented in this entry.Mitochondrial DNA depletion syndrome 8B (MTDPS8B) [MIM:612075]: A disease due to mitochondrial dysfunction and characterized by ophthalmoplegia, ptosis, gastrointestinal dysmotility, cachexia, peripheral neuropathy. {ECO:0000269PubMed:19667227}. Note=The disease is caused by mutations affecting the gene represented in this entry.Progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal dominant, 5 (PEOA5) [MIM:613077]: A disorder characterized by progressive weakness of ocular muscles and levator muscle of the upper eyelid. In a minority of cases, it is associated with skeletal myopathy, which predominantly involves axial or proximal muscles and which causes abnormal fatigability and even permanent muscle weakness. Ragged-red fibers and atrophy are found on muscle biopsy. A large proportion of chronic ophthalmoplegias are associated with other symptoms, leading to a multisystemic pattern of this disease. Additional symptoms are variable, and may include cataracts, hearing loss, sensory axonal neuropathy, ataxia, depression, hypogonadism, and parkinsonism. {ECO:0000269PubMed:19664747}. Note=The disease is caused by mutations affecting the gene represented in this entry.
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Tissue Specificity |
Widely expressed at a high level in skeletal muscle and at a weak level in thymus. Expressed in epithelial dysplasias and squamous cell carcinoma. {ECO:0000269PubMed:14583450}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
19
[view]
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Protein-Protein |
17
[view]
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Protein-DNA |
2
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0004748
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ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
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GO:0046872
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metal ion binding
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Biological Process |
GO:0009186
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deoxyribonucleoside diphosphate metabolic process
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GO:0015949
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nucleobase-containing small molecule interconversion
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GO:0044281
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small molecule metabolic process
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GO:0055086
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nucleobase-containing small molecule metabolic process
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GO:0055114
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oxidation-reduction process
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Cellular Component |
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PDB ID |
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InterPro |
IPR000358
Ribonucleotide reductase small subunit
IPR009078
Ferritin-like superfamily
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PFAM |
PF00268
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q7LG56
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PhosphoSite |
PhosphoSite-Q7LG56
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
50484
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UniGene |
Hs.609797
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RefSeq |
NP_001165949
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HUGO |
HGNC:17296
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OMIM |
604712
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CCDS |
CCDS55267
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HPRD |
05276
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IMGT |
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EMBL |
AB036063
AB036532
AB163437
AB163438
AB166669
AB166670
AB166671
AK001965
AK304354
AL137348
AP001328
AP002907
BC042468
BC108261
BC117496
BC130628
CH471060
DC308409
DQ027001
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GenPept |
AAH42468
AAI08262
AAI17497
AAI30629
AAY29059
BAA92005
BAA92434
BAA92493
BAD11774
BAD11775
BAD12265
BAD12266
BAD12267
BAG65196
CAB70703
EAW91842
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