InnateDB Protein
|
IDBP-238912.5
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
CXCL1
|
Protein Name
|
chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
|
Synonyms
|
FSP; GRO1; GROa; MGSA; MGSA-a; NAP-3; SCYB1;
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000379110
|
InnateDB Gene
|
IDBG-24070 (CXCL1)
|
Protein Structure
|
|
Function |
Has chemotactic activity for neutrophils. May play a role in inflammation and exerts its effects on endothelial cells in an autocrine fashion. In vitro, the processed forms GRO- alpha(4-73), GRO-alpha(5-73) and GRO-alpha(6-73) show a 30-fold higher chemotactic activity. {ECO:0000269PubMed:10095777}.
|
Subcellular Localization |
Secreted.
|
Disease Associations |
|
Tissue Specificity |
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
18
[view]
|
Protein-Protein |
15
[view]
|
Protein-DNA |
3
[view]
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
|
|
Molecular Function |
|
Biological Process |
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR001089
CXC chemokine
IPR001811
Chemokine interleukin-8-like domain
|
PFAM |
PF00048
|
PRINTS |
PR00437
|
PIRSF |
|
SMART |
SM00199
|
TIGRFAMs |
|
Modification |
|
SwissProt |
P09341
|
PhosphoSite |
PhosphoSite-
|
TrEMBL |
Q6LD34
|
UniProt Splice Variant |
|
Entrez Gene |
2919
|
UniGene |
Hs.789
|
RefSeq |
NP_001502
|
HUGO |
HGNC:4602
|
OMIM |
155730
|
CCDS |
CCDS47074
|
HPRD |
01119
|
IMGT |
|
EMBL |
BC011976
BT006880
J03561
U03018
X12510
X54489
|
GenPept |
AAA03452
AAA35933
AAH11976
AAP35526
CAA31027
CAA38361
|
|
|