InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TRIM71

Summary

InnateDB Protein

IDBP-23896.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TRIM71

Protein Name

tripartite motif containing 71

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000373272

InnateDB Gene

IDBG-23894 (TRIM71)

Protein Structure

UniProt Annotation

Function

E3 ubiquitin-protein ligase that cooperates with the microRNAs (miRNAs) machinery and promotes embryonic stem cells proliferation and maintenance. Binds to miRNAs and associates with AGO2, participating in post-transcriptional repression of transcripts such as CDKN1A. Facilitates the G1-S transition to promote rapid embryonic stem cell self-renewal by repressing CDKN1A expression. Required to maintain proliferation and prevent premature differentiation of neural progenitor cells during early neural development: positively regulates FGF signaling by controlling the stability of SHCBP1 (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm, P-body {ECO:0000250}.

Disease Associations

Tissue Specificity

Specifically expressed in testis. {ECO:0000269PubMed:15722555}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0035198	miRNA binding

Biological Process

GO:0000082	G1/S transition of mitotic cell cycle
GO:0001843	neural tube closure
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0010586	miRNA metabolic process
GO:0021915	neural tube development
GO:0035278	negative regulation of translation involved in gene silencing by miRNA
GO:0045087	innate immune response (InnateDB)
GO:0051246	regulation of protein metabolic process
GO:0051865	protein autoubiquitination
GO:0060964	regulation of gene silencing by miRNA
GO:0071310	cellular response to organic substance
GO:0072089	stem cell proliferation
GO:2000177	regulation of neural precursor cell proliferation
GO:2000637	positive regulation of gene silencing by miRNA

Cellular Component

GO:0000932	cytoplasmic mRNA processing body
GO:0005622	intracellular

Protein Structure and Domains

PDB ID

InterPro

IPR000315 Zinc finger, B-box
IPR001258 NHL repeat
IPR001298 Filamin/ABP280 repeat
IPR001841 Zinc finger, RING-type
IPR013017 NHL repeat, subgroup
IPR014756 Immunoglobulin E-set
IPR017868 Filamin/ABP280 repeat-like

PFAM

PF00643
PF01436
PF13639
PF14634
PF00630

PRINTS

PIRSF

SMART

SM00336
SM00557
SM00184

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q2Q1W2