InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SULT1A1

Summary

InnateDB Protein

IDBP-239192.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SULT1A1

Protein Name

sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1

Synonyms

HAST1/HAST2; P-PST; PST; ST1A1; ST1A3; STP; STP1; TSPST1;

Species

Homo sapiens

Ensembl Protein

ENSP00000378972

InnateDB Gene

IDBG-22979 (SULT1A1)

Protein Structure

UniProt Annotation

Function

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines, phenolic drugs and neurotransmitters. Has also estrogen sulfotransferase activity. responsible for the sulfonation and activation of minoxidil. Is Mediates the metabolic activation of carcinogenic N- hydroxyarylamines to DNA binding products and could so participate as modulating factor of cancer risk. {ECO:0000269PubMed:12471039, ECO:0000269PubMed:16221673}.

Subcellular Localization

Cytoplasm.

Disease Associations

Tissue Specificity

Liver, lung, adrenal, brain, platelets and skin.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 36 experimentally validated interaction(s) in this database.

Experimentally validated
Total	36 [view]
Protein-Protein	35 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004062	aryl sulfotransferase activity
GO:0008146	sulfotransferase activity
GO:0047894	flavonol 3-sulfotransferase activity
GO:0050294	steroid sulfotransferase activity

Biological Process

GO:0006584	catecholamine metabolic process
GO:0006805	xenobiotic metabolic process
GO:0008152	metabolic process
GO:0008210	estrogen metabolic process
GO:0009308	amine metabolic process
GO:0009812	flavonoid metabolic process
GO:0044281	small molecule metabolic process
GO:0050427	3'-phosphoadenosine 5'-phosphosulfate metabolic process
GO:0051923	sulfation