InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: LAT

Summary

InnateDB Protein

IDBP-23922.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LAT

Protein Name

linker for activation of T cells

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000354119

InnateDB Gene

IDBG-239499 (LAT)

Protein Structure

UniProt Annotation

Function

Required for TCR (T-cell antigen receptor)- and pre-TCR- mediated signaling, both in mature T-cells and during their development. Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules. {ECO:0000269PubMed:10072481}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:9489702, ECO:0000269PubMed:9729044}; Single-pass type III membrane protein {ECO:0000269PubMed:9489702, ECO:0000269PubMed:9729044}. Note=Present in lipid rafts.

Disease Associations

Tissue Specificity

Expressed in thymus, T-cells, NK cells, mast cells and, at lower levels, in spleen. Present in T-cells but not B-cells (at protein level). {ECO:0000269PubMed:16160011, ECO:0000269PubMed:9489702}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 66 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	66 [view]
Protein-Protein	66 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005070	SH3/SH2 adaptor activity
GO:0005515	protein binding
GO:0019901	protein kinase binding

Biological Process

GO:0006955	immune response
GO:0007165	signal transduction
GO:0007229	integrin-mediated signaling pathway
GO:0007265	Ras protein signal transduction
GO:0007596	blood coagulation
GO:0009967	positive regulation of signal transduction
GO:0019722	calcium-mediated signaling
GO:0030168	platelet activation
GO:0035556	intracellular signal transduction
GO:0038095	Fc-epsilon receptor signaling pathway
GO:0042110	T cell activation
GO:0043303	mast cell degranulation
GO:0045087	innate immune response (InnateDB)
GO:0050852	T cell receptor signaling pathway
GO:0050863	regulation of T cell activation

Cellular Component

GO:0001772	immunological synapse
GO:0005886	plasma membrane
GO:0008180	COP9 signalosome
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0042629	mast cell granule
GO:0045121	membrane raft