InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: VCPIP1

Summary

InnateDB Protein

IDBP-23940.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

VCPIP1

Protein Name

valosin containing protein (p97)/p47 complex interacting protein 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000309031

InnateDB Gene

IDBG-23938 (VCPIP1)

Protein Structure

UniProt Annotation

Function

Acts as a deubiquitinating enzyme. Necessary for VCP- mediated reassembly of Golgi stacks after mitosis. May play a role in VCP-mediated formation of transitional endoplasmic reticulum (tER). Mediates dissociation of the ternary complex containing STX5A, NSFL1C and VCP (By similarity). Hydrolyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitin chains. {ECO:0000250, ECO:0000269PubMed:23827681}.

Subcellular Localization

Endoplasmic reticulum {ECO:0000250}. Golgi apparatus, Golgi stack {ECO:0000250}. Note=Associated with Golgi stacks and endoplasmic reticulum. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 36 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	36 [view]
Protein-Protein	36 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004843	ubiquitin-specific protease activity

Biological Process

GO:0006508	proteolysis
GO:0007030	Golgi organization
GO:0007067	mitotic nuclear division
GO:0016320	endoplasmic reticulum membrane fusion
GO:0016567	protein ubiquitination
GO:0035871	protein K11-linked deubiquitination
GO:0071108	protein K48-linked deubiquitination
GO:0090168	Golgi reassembly