InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: LAT

Summary

InnateDB Protein

IDBP-239501.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LAT

Protein Name

linker for activation of T cells

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000378845

InnateDB Gene

IDBG-239499 (LAT)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 66 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	66 [view]
Protein-Protein	66 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005070	SH3/SH2 adaptor activity
GO:0005515	protein binding
GO:0019901	protein kinase binding

Biological Process

GO:0002260	lymphocyte homeostasis
GO:0006954	inflammatory response
GO:0006955	immune response
GO:0007229	integrin-mediated signaling pathway
GO:0007265	Ras protein signal transduction
GO:0007596	blood coagulation
GO:0009967	positive regulation of signal transduction
GO:0010467	gene expression
GO:0019722	calcium-mediated signaling
GO:0030168	platelet activation
GO:0035556	intracellular signal transduction
GO:0038095	Fc-epsilon receptor signaling pathway
GO:0042110	T cell activation
GO:0043303	mast cell degranulation
GO:0045087	innate immune response (InnateDB)
GO:0048872	homeostasis of number of cells
GO:0050852	T cell receptor signaling pathway
GO:0050863	regulation of T cell activation

Cellular Component

GO:0001772	immunological synapse
GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0008180	COP9 signalosome
GO:0016021	integral component of membrane
GO:0042629	mast cell granule
GO:0045121	membrane raft