InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: QPRT

Summary

InnateDB Protein

IDBP-239687.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

QPRT

Protein Name

quinolinate phosphoribosyltransferase

Synonyms

HEL-S-90n; QPRTase;

Species

Homo sapiens

Ensembl Protein

ENSP00000378782

InnateDB Gene

IDBG-24543 (QPRT)

Protein Structure

UniProt Annotation

Function

Involved in the catabolism of quinolinic acid (QA). {ECO:0000269PubMed:17868694}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004514	nicotinate-nucleotide diphosphorylase (carboxylating) activity
GO:0016763	transferase activity, transferring pentosyl groups
GO:0042803	protein homodimerization activity

Biological Process

GO:0006766	vitamin metabolic process
GO:0006767	water-soluble vitamin metabolic process
GO:0009435	NAD biosynthetic process
GO:0019363	pyridine nucleotide biosynthetic process
GO:0019674	NAD metabolic process
GO:0034213	quinolinate catabolic process
GO:0044281	small molecule metabolic process
GO:0051259	protein oligomerization

Cellular Component

GO:0005829	cytosol
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR002638 Quinolinate phosphoribosyl transferase, C-terminal
IPR004393 Nicotinate-nucleotide pyrophosphorylase
IPR022412 Quinolinate phosphoribosyl transferase, N-terminal

PFAM

PF01729
PF02749

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q15274

PhosphoSite