InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PTK2

Summary

InnateDB Protein

IDBP-239957.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PTK2

Protein Name

PTK2 protein tyrosine kinase 2

Synonyms

FADK; FAK; FAK1; FRNK; p125FAK; pp125FAK; PPP1R71;

Species

Homo sapiens

Ensembl Protein

ENSP00000378644

InnateDB Gene

IDBG-37147 (PTK2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 166 experimentally validated interaction(s) in this database.
They are also associated with 26 interaction(s) predicted by orthology.

Experimentally validated
Total	166 [view]
Protein-Protein	165 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	26 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004871	signal transducer activity
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006468	protein phosphorylation
GO:0007165	signal transduction
GO:0007172	signal complex assembly
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0045087	innate immune response (InnateDB)

Cellular Component

GO:0005856	cytoskeleton
GO:0005925	focal adhesion

Protein Structure and Domains

PDB ID

InterPro

IPR000299 FERM domain
IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR005189 Focal adhesion kinase, targeting (FAT) domain
IPR011009 Protein kinase-like domain
IPR019748 FERM central domain
IPR019749 Band 4.1 domain
IPR020635 Tyrosine-protein kinase, catalytic domain
IPR029071 Ubiquitin-related domain

PFAM

PF00069
PF07714
PF03623
PF00373

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00295
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt