InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: IL23R

Summary

InnateDB Protein

IDBP-239992.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IL23R

Protein Name

interleukin 23 receptor

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000378652

InnateDB Gene

IDBG-99558 (IL23R)

Protein Structure

UniProt Annotation

Function

Associates with IL12RB1 to form the interleukin-23 receptor. Binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. IL23 functions in innate and adaptive immunity and may participate in acute response to infection in peripheral tissues. IL23 may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis. {ECO:0000269PubMed:12023369}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:12023369}; Single-pass type I membrane protein {ECO:0000269PubMed:12023369}.

Disease Associations

Inflammatory bowel disease 17 (IBD17) [MIM:612261]: A chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints. {ECO:0000269PubMed:17068223, ECO:0000269PubMed:17804789}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.Psoriasis 7 (PSORS7) [MIM:605606]: A common, chronic inflammatory disease of the skin with multifactorial etiology. It is characterized by red, scaly plaques usually found on the scalp, elbows and knees. These lesions are caused by abnormal keratinocyte proliferation and infiltration of inflammatory cells into the dermis and epidermis. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Tissue Specificity

Expressed by monocytes, Th1, Th0, NK and dendritic cells. Isoform 1 is specifically expressed in NK cells. {ECO:0000269PubMed:12023369, ECO:0000269PubMed:16372191}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005143	interleukin-12 receptor binding
GO:0042019	interleukin-23 binding
GO:0042020	interleukin-23 receptor activity

Biological Process

GO:0001916	positive regulation of T cell mediated cytotoxicity
GO:0002230	positive regulation of defense response to virus by host
GO:0002827	positive regulation of T-helper 1 type immune response
GO:0006954	inflammatory response
GO:0010535	positive regulation of activation of JAK2 kinase activity
GO:0032496	response to lipopolysaccharide
GO:0032693	negative regulation of interleukin-10 production
GO:0032725	positive regulation of granulocyte macrophage colony-stimulating factor production
GO:0032729	positive regulation of interferon-gamma production
GO:0032735	positive regulation of interleukin-12 production
GO:0032740	positive regulation of interleukin-17 production
GO:0032819	positive regulation of natural killer cell proliferation
GO:0034341	response to interferon-gamma
GO:0038155	interleukin-23-mediated signaling pathway
GO:0042102	positive regulation of T cell proliferation
GO:0042104	positive regulation of activated T cell proliferation
GO:0042510	regulation of tyrosine phosphorylation of Stat1 protein
GO:0042517	positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0042520	positive regulation of tyrosine phosphorylation of Stat4 protein
GO:0042523	positive regulation of tyrosine phosphorylation of Stat5 protein
GO:0043382	positive regulation of memory T cell differentiation
GO:0045672	positive regulation of osteoclast differentiation
GO:0050829	defense response to Gram-negative bacterium
GO:0051135	positive regulation of NK T cell activation
GO:2000318	positive regulation of T-helper 17 type immune response
GO:2000330	positive regulation of T-helper 17 cell lineage commitment