Version 5.4
Homo sapiens Protein: AGPAT9
Summary
InnateDB Protein IDBP-239996.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AGPAT9
Protein Name 1-acylglycerol-3-phosphate O-acyltransferase 9
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000378651
InnateDB Gene IDBG-27850 (AGPAT9)
Protein Structure
UniProt Annotation
Function May transfer the acyl-group from acyl-coA to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis. Also transfers the acyl-group from acyl-coA to the sn-2 position of 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid, or LPA), forming 1,2-diacyl-sn-glycerol-3- phosphate (phosphatidic acid, or PA). {ECO:0000269PubMed:17002884, ECO:0000269PubMed:17170135, ECO:0000269PubMed:19318427}.
Subcellular Localization Endoplasmic reticulum membrane {ECO:0000269PubMed:17002884, ECO:0000269PubMed:19318427}; Multi- pass membrane protein {ECO:0000269PubMed:17002884, ECO:0000269PubMed:19318427}.
Disease Associations
Tissue Specificity Widely expressed. Expressed in liver, kidney, testis, brain, heart, skeletal muscle, thyroid, prostate, thymus and placenta. Also expressed lung and adipose tissue. {ECO:0000269PubMed:17002884, ECO:0000269PubMed:17170135}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity
GO:0004366 glycerol-3-phosphate O-acyltransferase activity
GO:0016746 transferase activity, transferring acyl groups
Biological Process
GO:0006644 phospholipid metabolic process
GO:0006654 phosphatidic acid biosynthetic process
GO:0008152 metabolic process
GO:0016024 CDP-diacylglycerol biosynthetic process
GO:0019432 triglyceride biosynthetic process
GO:0032006 regulation of TOR signaling
GO:0044255 cellular lipid metabolic process
GO:0044281 small molecule metabolic process
GO:0046474 glycerophospholipid biosynthetic process
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR002123 Phospholipid/glycerol acyltransferase
PFAM PF01553
PRINTS
PIRSF
SMART SM00563
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q53EU6
PhosphoSite PhosphoSite-Q53EU6
TrEMBL A0A024RDG5
UniProt Splice Variant
Entrez Gene 84803
UniGene Hs.99196
RefSeq NP_001243350
HUGO HGNC:28157
OMIM 610958
CCDS CCDS3606
HPRD 14417
IMGT
EMBL AB075872 AK055749 AK223543 AY358100 BC073136 BC090956 CH471057 DQ324782 DQ345298
GenPept AAH73136 AAH90956 AAQ88467 ABC55674 ABC70186 BAB71002 BAD38654 BAD97263 EAX05945 EAX05946

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca