InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PML

Summary

InnateDB Protein

IDBP-240142.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PML

Protein Name

promyelocytic leukemia

Synonyms

MYL; PP8675; RNF71; TRIM19;

Species

Homo sapiens

Ensembl Protein

ENSP00000378564

InnateDB Gene

IDBG-21462 (PML)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 277 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.

Experimentally validated
Total	277 [view]
Protein-Protein	275 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	22 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003713	transcription coactivator activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0031625	ubiquitin protein ligase binding
GO:0032183	SUMO binding
GO:0042803	protein homodimerization activity
GO:0046982	protein heterodimerization activity
GO:0050897	cobalt ion binding

Biological Process

GO:0001666	response to hypoxia
GO:0001932	regulation of protein phosphorylation
GO:0002230	positive regulation of defense response to virus by host
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006461	protein complex assembly
GO:0006605	protein targeting
GO:0006915	apoptotic process
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0007050	cell cycle arrest
GO:0008285	negative regulation of cell proliferation
GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage
GO:0010522	regulation of calcium ion transport into cytosol
GO:0016032	viral process
GO:0016525	negative regulation of angiogenesis
GO:0019221	cytokine-mediated signaling pathway
GO:0030308	negative regulation of cell growth
GO:0030578	PML body organization
GO:0031065	positive regulation of histone deacetylation
GO:0032211	negative regulation of telomere maintenance via telomerase
GO:0032469	endoplasmic reticulum calcium ion homeostasis
GO:0032922	circadian regulation of gene expression
GO:0032938	negative regulation of translation in response to oxidative stress
GO:0034097	response to cytokine
GO:0042752	regulation of circadian rhythm
GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0043153	entrainment of circadian clock by photoperiod
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045087	innate immune response (InnateDB)
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045930	negative regulation of mitotic cell cycle
GO:0050821	protein stabilization
GO:0051457	maintenance of protein location in nucleus
GO:0051607	defense response to virus
GO:0051974	negative regulation of telomerase activity
GO:0060058	positive regulation of apoptotic process involved in mammary gland involution
GO:0060333	interferon-gamma-mediated signaling pathway
GO:0090398	cellular senescence
GO:1902187	negative regulation of viral release from host cell
GO:2000059	negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:2000779	regulation of double-strand break repair
GO:2001238	positive regulation of extrinsic apoptotic signaling pathway

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0016363	nuclear matrix
GO:0016605	PML body
GO:0031901	early endosome membrane
GO:0031965	nuclear membrane
GO:0042406	extrinsic component of endoplasmic reticulum membrane