Version 5.4
Homo sapiens Protein: CLIP2
Summary
InnateDB Protein IDBP-240316.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CLIP2
Protein Name CAP-GLY domain containing linker protein 2
Synonyms CLIP; CLIP-115; CYLN2; WBSCR3; WBSCR4; WSCR3; WSCR4;
Species Homo sapiens
Ensembl Protein ENSP00000378500
InnateDB Gene IDBG-21163 (CLIP2)
Protein Structure
UniProt Annotation
Function Seems to link microtubules to dendritic lamellar body (DLB), a membranous organelle predominantly present in bulbous dendritic appendages of neurons linked by dendrodendritic gap junctions. May operate in the control of brain-specific organelle translocations (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Associated with the cytoskeleton. {ECO:0000250}.
Disease Associations Note=CLIP2 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Haploinsufficiency of CLIP2 may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in the disease.
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0016192 vesicle-mediated transport
Cellular Component
GO:0005875 microtubule associated complex
GO:0016020 membrane
Protein Structure and Domains
PDB ID
InterPro IPR000938 CAP Gly-rich domain
IPR010989 t-SNARE
PFAM PF01302
PRINTS
PIRSF
SMART SM01052
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9UDT6
PhosphoSite PhosphoSite-Q9UDT6
TrEMBL Q7Z5B7
UniProt Splice Variant
Entrez Gene 7461
UniGene Hs.647018
RefSeq
HUGO HGNC:2586
OMIM 603432
CCDS CCDS5569
HPRD 09140
IMGT
EMBL AB006629 AC005015 AF041055 AF041056 AF041057 AF041058 AF041059 AY295764
GenPept AAB96784 AAF03524 AAP91873 BAA22960

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca