InnateDB Protein
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IDBP-240357.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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RGS19
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Protein Name
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regulator of G-protein signaling 19
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Synonyms
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GAIP; RGSGAIP;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000378483
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InnateDB Gene
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IDBG-87816 (RGS19)
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Protein Structure
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Function |
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G-alpha subfamily 1 members, with the order G(i)a3 > G(i)a1 > G(o)a >> G(z)a/G(i)a2. Activity on G(z)-alpha is inhibited by phosphorylation and palmitoylation of the G-protein.
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Subcellular Localization |
Membrane; Lipid-anchor.
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Disease Associations |
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Tissue Specificity |
Highest expression in lung. Placenta, liver and heart also express high levels of GAIP.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated |
Total |
14
[view]
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Protein-Protein |
14
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
2 [view]
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Molecular Function |
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Biological Process |
GO:0006914
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autophagy
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GO:0007186
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G-protein coupled receptor signaling pathway
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GO:0007264
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small GTPase mediated signal transduction
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GO:0008277
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regulation of G-protein coupled receptor protein signaling pathway
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GO:0038032
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termination of G-protein coupled receptor signaling pathway
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GO:0043547
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positive regulation of GTPase activity
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Cellular Component |
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PDB ID |
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InterPro |
IPR000342
Regulator of G protein signalling domain
IPR016137
Regulator of G protein signalling superfamily
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PFAM |
PF00615
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PRINTS |
PR01301
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PIRSF |
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SMART |
SM00315
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TIGRFAMs |
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Modification |
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SwissProt |
P49795
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PhosphoSite |
PhosphoSite-P49795
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TrEMBL |
Q9H2T9
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UniProt Splice Variant |
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Entrez Gene |
10287
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UniGene |
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RefSeq |
NP_005864
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HUGO |
HGNC:13735
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OMIM |
605071
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CCDS |
CCDS13555
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HPRD |
05461
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IMGT |
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EMBL |
AF217688
AF493939
AK290081
AK298240
AL590548
AY585188
BC001318
BC054337
BC063010
BT009804
CH471077
X91809
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GenPept |
AAG42352
AAH01318
AAH54337
AAH63010
AAM12653
AAP88806
AAS94232
BAF82770
BAG60506
CAA62919
CAD11902
EAW75166
EAW75167
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