InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HIF1A

Summary

InnateDB Protein

IDBP-240420.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HIF1A

Protein Name

hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)

Synonyms

bHLHe78; HIF-1A; HIF-1alpha; HIF1; HIF1-ALPHA; MOP1; PASD8;

Species

Homo sapiens

Ensembl Protein

ENSP00000378446

InnateDB Gene

IDBG-8510 (HIF1A)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 258 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.

Experimentally validated
Total	262 [view]
Protein-Protein	220 [view]
Protein-DNA	38 [view]
Protein-RNA	1 [view]
DNA-DNA	3 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	21 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0046983	protein dimerization activity

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007165	signal transduction
GO:0045087	innate immune response (InnateDB)

Cellular Component

GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR000014 PAS domain
IPR001321 Hypoxia-inducible factor-1 alpha
IPR001610 PAC motif
IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
IPR013655 PAS fold-3
IPR013767 PAS fold
IPR014887 HIF-1 alpha, transactivation domain, C-terminal
IPR021537 Hypoxia-inducible factor, alpha subunit

PFAM