InnateDB Protein
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IDBP-240668.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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CDC23
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Protein Name
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cell division cycle 23 homolog (S. cerevisiae)
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Synonyms
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ANAPC8; APC8; CUT23;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000378348
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InnateDB Gene
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IDBG-46810 (CDC23)
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Protein Structure
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Function |
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. {ECO:0000269PubMed:18485873}.
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Subcellular Localization |
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 91 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
91
[view]
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Protein-Protein |
87
[view]
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Protein-DNA |
4
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0004842
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ubiquitin-protein transferase activity
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Biological Process |
GO:0000080
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mitotic G1 phase
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GO:0000278
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mitotic cell cycle
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GO:0006511
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ubiquitin-dependent protein catabolic process
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GO:0007049
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cell cycle
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GO:0007067
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mitotic nuclear division
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GO:0007080
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mitotic metaphase plate congression
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GO:0007091
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metaphase/anaphase transition of mitotic cell cycle
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GO:0007094
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mitotic spindle assembly checkpoint
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GO:0007096
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regulation of exit from mitosis
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GO:0030071
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regulation of mitotic metaphase/anaphase transition
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GO:0031145
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anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
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GO:0051436
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negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
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GO:0051437
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positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
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GO:0051439
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regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
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GO:0070979
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protein K11-linked ubiquitination
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Cellular Component |
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PDB ID |
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InterPro |
IPR007192
Cdc23
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PFAM |
PF04049
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9UJX2
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PhosphoSite |
PhosphoSite-Q9UJX2
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
8697
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UniGene |
Hs.73625
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RefSeq |
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HUGO |
HGNC:1724
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OMIM |
603462
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CCDS |
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HPRD |
07221
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IMGT |
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EMBL |
AB011472
AC106752
AF053977
AF191341
AK223250
AK291610
AK304635
AY603103
BC005258
BC010944
BC017713
BT009810
CH471062
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GenPept |
AAC70920
AAF05755
AAH05258
AAH10944
AAH17713
AAP88812
AAS99353
BAA75628
BAD96970
BAF84299
BAG65414
EAW62154
EAW62155
EAW62156
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