InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PPP3CA

Summary

InnateDB Protein

IDBP-240741.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PPP3CA

Protein Name

protein phosphatase 3, catalytic subunit, alpha isozyme

Synonyms

CALN; CALNA; CALNA1; CCN1; CNA1; PPP2B;

Species

Homo sapiens

Ensembl Protein

ENSP00000378323

InnateDB Gene

IDBG-31818 (PPP3CA)

Protein Structure

UniProt Annotation

Function

Calcium-dependent, calmodulin-stimulated protein phosphatase. Many of the substrates contain a PxIxIT motif. This subunit may have a role in the calmodulin activation of calcineurin. Dephosphorylates DNM1L, HSPB1 and SSH1. {ECO:0000269PubMed:15671020, ECO:0000269PubMed:17498738, ECO:0000269PubMed:18838687}.

Subcellular Localization

Cell membrane {ECO:0000250}. Cell membrane, sarcolemma {ECO:0000250}. Nucleus {ECO:0000250}. Note=Colocalizes with ACTN1 and MYOZ2 at the Z line in heart and skeletal muscle. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 66 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	66 [view]
Protein-Protein	64 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004721	phosphoprotein phosphatase activity
GO:0004722	protein serine/threonine phosphatase activity
GO:0004723	calcium-dependent protein serine/threonine phosphatase activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0008144	drug binding
GO:0016787	hydrolase activity
GO:0019899	enzyme binding
GO:0033192	calmodulin-dependent protein phosphatase activity
GO:0046982	protein heterodimerization activity
GO:0046983	protein dimerization activity

Biological Process

GO:0000082	G1/S transition of mitotic cell cycle
GO:0001975	response to amphetamine
GO:0006470	protein dephosphorylation
GO:0006606	protein import into nucleus
GO:0006816	calcium ion transport
GO:0014883	transition between fast and slow fiber
GO:0016311	dephosphorylation
GO:0019722	calcium-mediated signaling
GO:0033173	calcineurin-NFAT signaling cascade
GO:0033555	multicellular organismal response to stress
GO:0035690	cellular response to drug
GO:0038095	Fc-epsilon receptor signaling pathway
GO:0042110	T cell activation
GO:0045087	innate immune response (InnateDB)
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046676	negative regulation of insulin secretion
GO:0048741	skeletal muscle fiber development
GO:0050804	regulation of synaptic transmission
GO:0051592	response to calcium ion
GO:0060079	regulation of excitatory postsynaptic membrane potential
GO:0071333	cellular response to glucose stimulus

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005829	cytosol
GO:0005955	calcineurin complex
GO:0016020	membrane
GO:0030018	Z disc
GO:0042383	sarcolemma

Protein Structure and Domains

PDB ID

InterPro

IPR004843 Calcineurin-like phosphoesterase domain, apaH type
IPR006186 Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase
IPR029052 Metallo-dependent phosphatase-like

PFAM

PF00149

PRINTS

PR00114

PIRSF

SMART

SM00156

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt