InnateDB Protein
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IDBP-240743.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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PPP3CA
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Protein Name
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protein phosphatase 3, catalytic subunit, alpha isozyme
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Synonyms
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CALN; CALNA; CALNA1; CCN1; CNA1; PPP2B;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000378322
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InnateDB Gene
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IDBG-31818 (PPP3CA)
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Protein Structure
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Function |
Calcium-dependent, calmodulin-stimulated protein phosphatase. Many of the substrates contain a PxIxIT motif. This subunit may have a role in the calmodulin activation of calcineurin. Dephosphorylates DNM1L, HSPB1 and SSH1. {ECO:0000269PubMed:15671020, ECO:0000269PubMed:17498738, ECO:0000269PubMed:18838687}.
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Subcellular Localization |
Cell membrane {ECO:0000250}. Cell membrane, sarcolemma {ECO:0000250}. Nucleus {ECO:0000250}. Note=Colocalizes with ACTN1 and MYOZ2 at the Z line in heart and skeletal muscle. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 66 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Experimentally validated |
Total |
66
[view]
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Protein-Protein |
64
[view]
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Protein-DNA |
2
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
12 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR004843
Calcineurin-like phosphoesterase domain, apaH type
IPR006186
Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase
IPR029052
Metallo-dependent phosphatase-like
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PFAM |
PF00149
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PRINTS |
PR00114
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PIRSF |
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SMART |
SM00156
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TIGRFAMs |
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Modification |
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SwissProt |
Q08209
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PhosphoSite |
PhosphoSite-Q08209
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TrEMBL |
Q9UMB2
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UniProt Splice Variant |
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Entrez Gene |
5530
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UniGene |
Hs.706046
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RefSeq |
NP_001124163
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HUGO |
HGNC:9314
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OMIM |
114105
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CCDS |
CCDS47114
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HPRD |
00234
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IMGT |
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EMBL |
AB451338
AB451487
AC092671
AK290532
AL353950
AP001816
AP001870
AP001939
AY904364
BC025714
CH471057
EU192652
EU192653
L14778
S40012
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GenPept |
AAA02631
AAB22473
AAH25714
AAY17314
ABW74484
ABW74485
BAF83221
BAG70152
BAG70301
CAB89253
EAX06124
EAX06125
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