InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NR4A1

Summary

InnateDB Protein

IDBP-240797.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NR4A1

Protein Name

nuclear receptor subfamily 4, group A, member 1

Synonyms

GFRP1; HMR; N10; NAK-1; NGFIB; NP10; NUR77; TR3;

Species

Homo sapiens

Ensembl Protein

ENSP00000378302

InnateDB Gene

IDBG-33982 (NR4A1)

Protein Structure

UniProt Annotation

Function

Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'- AAAAGGTCA-3' (By similarity). May inhibit NF-kappa-B transactivation of IL2. Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation. {ECO:0000250, ECO:0000269PubMed:15466594, ECO:0000269PubMed:22983157}.

Subcellular Localization

Cytoplasm. Nucleus.

Disease Associations

Tissue Specificity

Fetal muscle and adult liver, brain and thyroid.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 124 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	124 [view]
Protein-Protein	122 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003707	steroid hormone receptor activity
GO:0004879	ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0001938	positive regulation of endothelial cell proliferation
GO:0002042	cell migration involved in sprouting angiogenesis
GO:0006355	regulation of transcription, DNA-templated
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0007165	signal transduction
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0010467	gene expression
GO:0030522	intracellular receptor signaling pathway
GO:0035767	endothelial cell chemotaxis
GO:0035924	cellular response to vascular endothelial growth factor stimulus
GO:0038095	Fc-epsilon receptor signaling pathway
GO:0043401	steroid hormone mediated signaling pathway
GO:0044344	cellular response to fibroblast growth factor stimulus
GO:0045087	innate immune response
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0048015	phosphatidylinositol-mediated signaling

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR000536 Nuclear hormone receptor, ligand-binding, core
IPR001628 Zinc finger, nuclear hormone receptor-type
IPR001723 Steroid hormone receptor
IPR003070 Orphan nuclear receptor
IPR003071 Orphan nuclear receptor, HMR type
IPR008946 Nuclear hormone receptor, ligand-binding

PFAM

PF00104
PF00105

PRINTS

PR00047
PR00398
PR01284
PR01285

PIRSF

SMART

SM00430
SM00399

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt