InnateDB Protein
|
IDBP-240810.5
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
INCENP
|
Protein Name
|
inner centromere protein antigens 135/155kDa
|
Synonyms
|
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000378295
|
InnateDB Gene
|
IDBG-50806 (INCENP)
|
Protein Structure
|
|
Function |
Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Probably acts through association with AURKB or AURKC. Seems to bind directly to microtubules. Controls the kinetochore localization of BUB1. {ECO:0000269PubMed:12925766, ECO:0000269PubMed:15316025, ECO:0000269PubMed:16760428}.
|
Subcellular Localization |
Chromosome, centromere. Cytoplasm, cytoskeleton, spindle. Nucleus. Chromosome, centromere, kinetochore. Note=Localizes to inner kinetochore. Localizes on chromosome arms and inner centromeres from prophase through metaphase and then transferring to the spindle midzone and midbody from anaphase through cytokinesis. Colocalizes with AURKB at mitotic chromosomes.
|
Disease Associations |
|
Tissue Specificity |
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 38 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
38
[view]
|
Protein-Protein |
35
[view]
|
Protein-DNA |
3
[view]
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
|
|
Molecular Function |
|
Biological Process |
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR005635
Inner centromere protein, ARK-binding domain
IPR022006
Chromosome passenger complex (CPC) protein INCENP N-terminal
|
PFAM |
PF03941
PF12178
|
PRINTS |
|
PIRSF |
|
SMART |
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q9NQS7
|
PhosphoSite |
PhosphoSite-Q9NQS7
|
TrEMBL |
E9PM67
|
UniProt Splice Variant |
|
Entrez Gene |
3619
|
UniGene |
Hs.142179
|
RefSeq |
NP_001035784
|
HUGO |
HGNC:6058
|
OMIM |
604411
|
CCDS |
CCDS44624
|
HPRD |
05103
|
IMGT |
|
EMBL |
AF282265
AP002793
AY714053
BC098576
CH471076
|
GenPept |
AAF87584
AAH98576
AAU04398
EAW74004
|
|
|