Version 5.4
Homo sapiens Protein: GPR75
Summary
InnateDB Protein IDBP-241057.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GPR75
Protein Name G protein-coupled receptor 75
Synonyms GPRchr2; WI31133;
Species Homo sapiens
Ensembl Protein ENSP00000378195
InnateDB Gene IDBG-51758 (GPR75)
Protein Structure
UniProt Annotation
Function Orphan receptor.
Subcellular Localization Cell membrane; Multi-pass membrane protein.
Disease Associations
Tissue Specificity Expressed at high levels in brain and spinal cord and at detectable levels in retinal pigment epithelium. In situ hybridization of adult eye sections localized transcripts only to the perivascular cells, surrounding retinal arterioles, in the ganglion cell/nerve fiber layer. {ECO:0000269PubMed:10381362}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004930 G-protein coupled receptor activity
Biological Process
GO:0007186 G-protein coupled receptor signaling pathway
Cellular Component
GO:0005887 integral component of plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
IPR017452 GPCR, rhodopsin-like, 7TM
PFAM PF00001
PRINTS PR00237
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O95800
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 10936
UniGene
RefSeq NP_006785
HUGO HGNC:4526
OMIM 606704
CCDS CCDS1849
HPRD 09462
IMGT
EMBL AC008068 AF072693 AF101472 AK314885 BC067475 BC067476 CH471053
GenPept AAD19849 AAD22770 AAH67475 AAH67476 AAY15018 BAG37399 EAX00162

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca