InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: BRD7

Summary

InnateDB Protein

IDBP-241069.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BRD7

Protein Name

bromodomain containing 7

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000378180

InnateDB Gene

IDBG-30500 (BRD7)

Protein Structure

UniProt Annotation

Function

Acts both as coactivator and as corepressor. May play a role in chromatin remodeling. Activator of the Wnt signaling pathway in a DVL1-dependent manner by negatively regulating the GSK3B phosphotransferase activity. Induces dephosphorylation of GSK3B at 'Tyr-216'. Down-regulates TRIM24-mediated activation of transcriptional activation by AR (By similarity). Transcriptional corepressor that down-regulates the expression of target genes. Binds to target promoters, leading to increased histone H3 acetylation at 'Lys-9' (H3K9ac). Binds to the ESR1 promoter. Recruits BRCA1 and POU2F1 to the ESR1 promoter. Coactivator for TP53-mediated activation of transcription of a set of target genes. Required for TP53-mediated cell-cycle arrest in response to oncogene activation. Promotes acetylation of TP53 at 'Lys-382', and thereby promotes efficient recruitment of TP53 to target promoters. Inhibits cell cycle progression from G1 to S phase. {ECO:0000250, ECO:0000269PubMed:16265664, ECO:0000269PubMed:16475162, ECO:0000269PubMed:20215511, ECO:0000269PubMed:20228809, ECO:0000269PubMed:20660729}.

Subcellular Localization

Isoform 2: Nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 62 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	62 [view]
Protein-Protein	62 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002039	p53 binding
GO:0003713	transcription coactivator activity
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0042393	histone binding
GO:0044212	transcription regulatory region DNA binding
GO:0070577	lysine-acetylated histone binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0007049	cell cycle
GO:0008285	negative regulation of cell proliferation
GO:0016055	Wnt signaling pathway
GO:0035066	positive regulation of histone acetylation
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:2000134	negative regulation of G1/S transition of mitotic cell cycle