Version 5.4
Homo sapiens Protein: IL16
Summary
InnateDB Protein IDBP-241106.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IL16
Protein Name interleukin 16
Synonyms LCF; NIL16; prIL-16; PRIL16;
Species Homo sapiens
Ensembl Protein ENSP00000378155
InnateDB Gene IDBG-25974 (IL16)
Protein Structure
UniProt Annotation
Function Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4.Isoform 1 may act as a scaffolding protein that anchors ion channels in the membrane.Isoform 3 is involved in cell cycle progression in T- cells. Appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. May act as a scaffold for GABPB1 (the DNA-binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells.
Subcellular Localization Interleukin-16: Secreted.Isoform 1: Cytoplasm {ECO:0000250}.Isoform 3: Cytoplasm. Nucleus.
Disease Associations
Tissue Specificity Isoform 3 is expressed in hemopoietic tissues, such as resting T-cells, but is undetectable during active T-cell proliferation.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 52 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Experimentally validated
Total 52 [view]
Protein-Protein 49 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006955 immune response
GO:0016032 viral process
Cellular Component
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
Protein Structure and Domains
PDB ID
InterPro IPR001478 PDZ domain
IPR020450 Interleukin-16
PFAM PF00595
PF13180
PRINTS PR01931
PIRSF
SMART SM00228
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q14005
PhosphoSite PhosphoSite-Q14005
TrEMBL H0YLL1
UniProt Splice Variant
Entrez Gene 3603
UniGene Hs.585683
RefSeq NP_001165599
HUGO HGNC:5980
OMIM 603035
CCDS CCDS53966
HPRD 04329
IMGT
EMBL AC036196 AC103858 AF053412 AF077011 AK131530 AY324389 AY497901 BC136660 M90391 S81601
GenPept AAB36371 AAC12732 AAD04636 AAD15990 AAI36661 AAQ86961 AAR89904 BAD18668

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca