InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CCL8

Summary

InnateDB Protein

IDBP-241225.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CCL8

Protein Name

chemokine (C-C motif) ligand 8

Synonyms

HC14; MCP-2; MCP2; SCYA10; SCYA8;

Species

Homo sapiens

Ensembl Protein

ENSP00000378118

InnateDB Gene

IDBG-40686 (CCL8)

Protein Structure

UniProt Annotation

Function

Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils. May play a role in neoplasia and inflammatory host responses. This protein can bind heparin. The processed form MCP-2(6-76) does not show monocyte chemotactic activity, but inhibits the chemotactic effect most predominantly of CCL7, and also of CCL2 and CCL5 and CCL8. {ECO:0000269PubMed:9558113}.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Highest expression found in the small intestine and peripheral blood cells. Intermediate levels seen in the heart, placenta, lung, skeletal muscle, thymus, colon, ovary, spinal cord and pancreas. Low levels seen in the brain, liver, spleen and prostate.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.

Experimentally validated
Total	16 [view]
Protein-Protein	14 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0008009	chemokine activity
GO:0008201	heparin binding
GO:0016004	phospholipase activator activity

Biological Process

GO:0006468	protein phosphorylation
GO:0006816	calcium ion transport
GO:0006874	cellular calcium ion homeostasis
GO:0006887	exocytosis
GO:0006935	chemotaxis
GO:0006954	inflammatory response
GO:0006955	immune response
GO:0007165	signal transduction
GO:0007267	cell-cell signaling
GO:0009615	response to virus
GO:0043085	positive regulation of catalytic activity
GO:0060326	cell chemotaxis