InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MAX

Summary

InnateDB Protein

IDBP-241232.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MAX

Protein Name

MYC associated factor X

Synonyms

bHLHd4;

Species

Homo sapiens

Ensembl Protein

ENSP00000378104

InnateDB Gene

IDBG-9524 (MAX)

Protein Structure

UniProt Annotation

Function

Transcription regulator. Forms a sequence-specific DNA- binding protein complex with MYC or MAD which recognizes the core sequence 5'-CAC[GA]TG-3'. The MYC:MAX complex is a transcriptional activator, whereas the MAD:MAX complex is a repressor. May repress transcription via the recruitment of a chromatin remodeling complex containing H3 'Lys-9' histone methyltransferase activity.

Subcellular Localization

Nucleus. Cell projection, dendrite {ECO:0000250}.

Disease Associations

Tissue Specificity

High levels found in the brain, heart and lung while lower levels are seen in the liver, kidney and skeletal muscle.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 817 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.

Experimentally validated
Total	817 [view]
Protein-Protein	87 [view]
Protein-DNA	730 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	16 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003712	transcription cofactor activity
GO:0003713	transcription coactivator activity
GO:0005515	protein binding
GO:0046983	protein dimerization activity