InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FUT8

Summary

InnateDB Protein

IDBP-241268.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FUT8

Protein Name

fucosyltransferase 8 (alpha (1,6) fucosyltransferase)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000378087

InnateDB Gene

IDBG-9620 (FUT8)

Protein Structure

UniProt Annotation

Function

Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans. {ECO:0000269PubMed:17172260, ECO:0000269PubMed:9133635}.

Subcellular Localization

Golgi apparatus, Golgi stack membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Note=Membrane-bound form in trans cisternae of Golgi. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008424	glycoprotein 6-alpha-L-fucosyltransferase activity
GO:0017124	SH3 domain binding

Biological Process

GO:0001701	in utero embryonic development
GO:0006487	protein N-linked glycosylation
GO:0006491	N-glycan processing
GO:0009312	oligosaccharide biosynthetic process
GO:0018279	protein N-linked glycosylation via asparagine
GO:0033578	protein glycosylation in Golgi
GO:0036071	N-glycan fucosylation
GO:0042355	L-fucose catabolic process
GO:0043687	post-translational protein modification
GO:0044267	cellular protein metabolic process
GO:0046368	GDP-L-fucose metabolic process

Cellular Component

GO:0000139	Golgi membrane
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0032580	Golgi cisterna membrane
GO:0070062	extracellular vesicular exosome