InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SLC2A4

Summary

InnateDB Protein

IDBP-24144.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC2A4

Protein Name

solute carrier family 2 (facilitated glucose transporter), member 4

Synonyms

GLUT4;

Species

Homo sapiens

Ensembl Protein

ENSP00000320935

InnateDB Gene

IDBG-24140 (SLC2A4)

Protein Structure

UniProt Annotation

Function

Insulin-regulated facilitative glucose transporter.

Subcellular Localization

Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Endomembrane system {ECO:0000269PubMed:8300557}; Multi-pass membrane protein {ECO:0000269PubMed:8300557}. Cytoplasm, perinuclear region {ECO:0000269PubMed:8300557}. Note=Localizes primarily to the perinuclear region, undergoing continued recycling to the plasma membrane where it is rapidly reinternalized. The dileucine internalization motif is critical for intracellular sequestration.

Disease Associations

Diabetes mellitus, non-insulin-dependent (NIDDM) [MIM:125853]: A multifactorial disorder of glucose homeostasis caused by a lack of sensitivity to the body's own insulin. Affected individuals usually have an obese body habitus and manifestations of a metabolic syndrome characterized by diabetes, insulin resistance, hypertension and hypertriglyceridemia. The disease results in long-term complications that affect the eyes, kidneys, nerves, and blood vessels. {ECO:0000269PubMed:1521731, ECO:0000269PubMed:1756912, ECO:0000269PubMed:1918382}. Note=The disease may be caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Skeletal and cardiac muscles; brown and white fat.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 41 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	41 [view]
Protein-Protein	39 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005355	glucose transmembrane transporter activity
GO:0005515	protein binding
GO:0022857	transmembrane transporter activity
GO:0022891	substrate-specific transmembrane transporter activity
GO:0055056	D-glucose transmembrane transporter activity

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0008645	hexose transport
GO:0010021	amylopectin biosynthetic process
GO:0015758	glucose transport
GO:0032869	cellular response to insulin stimulus
GO:0042593	glucose homeostasis
GO:0044281	small molecule metabolic process
GO:0045471	response to ethanol
GO:0046323	glucose import
GO:0050873	brown fat cell differentiation
GO:0055085	transmembrane transport
GO:0061024	membrane organization
GO:0071456	cellular response to hypoxia
GO:0071470	cellular response to osmotic stress

Cellular Component

GO:0005768	endosome
GO:0005771	multivesicular body
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0005905	coated pit
GO:0009897	external side of plasma membrane
GO:0009986	cell surface
GO:0012505	endomembrane system
GO:0012506	vesicle membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030136	clathrin-coated vesicle
GO:0030140	trans-Golgi network transport vesicle
GO:0030315	T-tubule
GO:0031982	vesicle
GO:0032593	insulin-responsive compartment
GO:0042383	sarcolemma
GO:0043231	intracellular membrane-bounded organelle
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR002441 Glucose transporter, type 4 (GLUT4)
IPR003663 Sugar/inositol transporter
IPR005828 General substrate transporter
IPR011701 Major facilitator superfamily
IPR016196 Major facilitator superfamily domain, general substrate transporter
IPR020846 Major facilitator superfamily domain

PFAM

PF00083
PF07690

PRINTS

PR01193
PR00171

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P14672