InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: COPS5

Summary

InnateDB Protein

IDBP-24193.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

COPS5

Protein Name

COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis)

Synonyms

CSN5; JAB1; MOV-34; SGN5;

Species

Homo sapiens

Ensembl Protein

ENSP00000350512

InnateDB Gene

IDBG-24191 (COPS5)

Protein Structure

UniProt Annotation

Function

Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. In the complex, it probably acts as the catalytic center that mediates the cleavage of Nedd8 from cullins. It however has no metalloprotease activity by itself and requires the other subunits of the CSN complex. Interacts directly with a large number of proteins that are regulated by the CSN complex, confirming a key role in the complex. Promotes the proteasomal degradation of BRSK2. {ECO:0000269PubMed:11285227, ECO:0000269PubMed:11337588, ECO:0000269PubMed:12628923, ECO:0000269PubMed:12732143, ECO:0000269PubMed:19214193, ECO:0000269PubMed:22609399, ECO:0000269PubMed:9535219}.

Subcellular Localization

Cytoplasm. Nucleus. Cytoplasm, perinuclear region. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle. Note=Nuclear localization is diminished in the presence of IFIT3.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 856 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Experimentally validated
Total	856 [view]
Protein-Protein	856 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003713	transcription coactivator activity
GO:0003743	translation initiation factor activity
GO:0004843	ubiquitin-specific protease activity
GO:0005515	protein binding
GO:0008237	metallopeptidase activity
GO:0046872	metal ion binding

Biological Process

GO:0000338	protein deneddylation
GO:0006366	transcription from RNA polymerase II promoter
GO:0006412	translation
GO:0006413	translational initiation
GO:0006508	proteolysis
GO:0010388	cullin deneddylation
GO:0016579	protein deubiquitination
GO:0045087	innate immune response (InnateDB)
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046328	regulation of JNK cascade
GO:0051726	regulation of cell cycle
GO:1990182	exosomal secretion

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005852	eukaryotic translation initiation factor 3 complex
GO:0008021	synaptic vesicle
GO:0008180	COP9 signalosome
GO:0030054	cell junction
GO:0048471	perinuclear region of cytoplasm