InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MIEN1

Summary

InnateDB Protein

IDBP-242024.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MIEN1

Protein Name

migration and invasion enhancer 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000377778

InnateDB Gene

IDBG-46188 (MIEN1)

Protein Structure

UniProt Annotation

Function

Increases cell migration by inducing filopodia formation at the leading edge of migrating cells. Plays a role in regulation of apoptosis, possibly through control of CASP3. May be involved in a redox-related process. {ECO:0000269PubMed:19503095, ECO:0000269PubMed:21628459}.

Subcellular Localization

Cytoplasm, cytosol. Cell membrane; Lipid- anchor; Cytoplasmic side. Note=Concentrates at the leading edge of migrating cells. Localizes outside membrane raft regions.

Disease Associations

Tissue Specificity

Among normal tissues, present only in Leydig cells. Strongly up-regulated in breast cancers and in brain cancer distant metastasis (at protein level). Up-regulated in prostate cancer cells and in the higher grades of prostate adenocarcinoma (at protein level). {ECO:0000269PubMed:17121940, ECO:0000269PubMed:19503095}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008430	selenium binding

Biological Process

GO:0006915	apoptotic process
GO:0030335	positive regulation of cell migration
GO:0043066	negative regulation of apoptotic process
GO:0045454	cell redox homeostasis
GO:0051491	positive regulation of filopodium assembly