InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NIT2

Summary

InnateDB Protein

IDBP-242214.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NIT2

Protein Name

nitrilase family, member 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000377696

InnateDB Gene

IDBG-47288 (NIT2)

Protein Structure

UniProt Annotation

Function

Has a omega-amidase activity. The role of omega-amidase is to remove potentially toxic intermediates by converting alpha- ketoglutaramate and alpha-ketosuccinamate to biologically useful alpha-ketoglutarate and oxaloacetate, respectively. Overexpression decreases the colony-forming capacity of cultured cells by arresting cells in the G2 phase of the cell cycle. {ECO:0000269PubMed:17488281, ECO:0000269PubMed:19595734}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:17488281}.

Disease Associations

Tissue Specificity

Detected in fetal brain (at protein level). Ubiquitous. Detected in heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, prostate, spleen, thymus, prostate, testis, ovary, small intestine and colon. {ECO:0000269PubMed:14528910, ECO:0000269PubMed:17488281}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.

Experimentally validated
Total	15 [view]
Protein-Protein	15 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
GO:0050152	omega-amidase activity

Biological Process

GO:0006107	oxaloacetate metabolic process
GO:0006528	asparagine metabolic process
GO:0006541	glutamine metabolic process
GO:0006807	nitrogen compound metabolic process