InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: THRA

Summary

InnateDB Protein

IDBP-242230.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

THRA

Protein Name

thyroid hormone receptor, alpha

Synonyms

AR7; c-ERBA-1; CHNG6; EAR7; ERB-T-1; ERBA; ERBA1; NR1A1; THRA1; THRA2;

Species

Homo sapiens

Ensembl Protein

ENSP00000377679

InnateDB Gene

IDBG-47063 (THRA)

Protein Structure

UniProt Annotation

Function

Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine. {ECO:0000269PubMed:12699376, ECO:0000269PubMed:14673100, ECO:0000269PubMed:18237438, ECO:0000269PubMed:19926848}.

Subcellular Localization

Nucleus.

Disease Associations

Hypothyroidism, congenital, non-goitrous, 6 (CHNG6) [MIM:614450]: A disease characterized by growth retardation, developmental retardation, skeletal dysplasia, borderline low thyroxine levels and high triiodothyronine levels. There is differential sensitivity to thyroid hormone action, with retention of hormone responsiveness in the hypothalamic pituitary axis and liver but skeletal, gastrointestinal, and myocardial resistance. {ECO:0000269PubMed:22168587}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 89 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	89 [view]
Protein-Protein	88 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003707	steroid hormone receptor activity
GO:0004887	thyroid hormone receptor activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0008270	zinc ion binding
GO:0017025	TBP-class protein binding
GO:0019904	protein domain specific binding
GO:0043565	sequence-specific DNA binding
GO:0044212	transcription regulatory region DNA binding
GO:0070324	thyroid hormone binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0009755	hormone-mediated signaling pathway
GO:0010467	gene expression
GO:0017055	negative regulation of RNA polymerase II transcriptional preinitiation complex assembly
GO:0043401	steroid hormone mediated signaling pathway
GO:0045892	negative regulation of transcription, DNA-templated
GO:2000143	negative regulation of DNA-dependent transcription, initiation

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

InterPro

IPR000536 Nuclear hormone receptor, ligand-binding, core
IPR001628 Zinc finger, nuclear hormone receptor-type
IPR001723 Steroid hormone receptor
IPR001728 Thyroid hormone receptor
IPR008946 Nuclear hormone receptor, ligand-binding

PFAM

PF00104
PF00105

PRINTS

PR00047
PR00398
PR00546

PIRSF

SMART

SM00430
SM00399

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt