InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RARA

Summary

InnateDB Protein

IDBP-242297.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RARA

Protein Name

retinoic acid receptor, alpha

Synonyms

NR1B1; RAR;

Species

Homo sapiens

Ensembl Protein

ENSP00000377648

InnateDB Gene

IDBG-47411 (RARA)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 188 experimentally validated interaction(s) in this database.
They are also associated with 62 interaction(s) predicted by orthology.

Experimentally validated
Total	188 [view]
Protein-Protein	179 [view]
Protein-DNA	7 [view]
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	62 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003707	steroid hormone receptor activity
GO:0003708	retinoic acid receptor activity
GO:0008270	zinc ion binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0043401	steroid hormone mediated signaling pathway
GO:0048384	retinoic acid receptor signaling pathway

Cellular Component

GO:0005634

nucleus

Protein Structure and Domains

PDB ID

InterPro

IPR000003 Retinoid X receptor/HNF4
IPR000536 Nuclear hormone receptor, ligand-binding, core
IPR001628 Zinc finger, nuclear hormone receptor-type
IPR001723 Steroid hormone receptor
IPR003070 Orphan nuclear receptor
IPR003078 Retinoic acid receptor
IPR008946 Nuclear hormone receptor, ligand-binding

PFAM

PF00104
PF00105

PRINTS

PR00545
PR00047
PR00398
PR01284
PR01292

PIRSF

SMART

SM00430
SM00399

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt