InnateDB Protein
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IDBP-242555.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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PTTG1
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Protein Name
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pituitary tumor-transforming 1
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Synonyms
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EAP1; HPTTG; PTTG; TUTR1;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000377536
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InnateDB Gene
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IDBG-56181 (PTTG1)
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Protein Structure
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Function |
Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1. Its function is however not limited to a blocking activity, since it is required to activate ESPL1. Negatively regulates the transcriptional activity and related apoptosis activity of TP53. The negative regulation of TP53 may explain the strong transforming capability of the protein when it is overexpressed. May also play a role in DNA repair via its interaction with Ku, possibly by connecting DNA damage-response pathways with sister chromatid separation. {ECO:0000269PubMed:10411507, ECO:0000269PubMed:11238996, ECO:0000269PubMed:11371342, ECO:0000269PubMed:12355087}.
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Subcellular Localization |
Cytoplasm. Nucleus.
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Disease Associations |
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Tissue Specificity |
Expressed at low level in most tissues, except in adult testis, where it is highly expressed. Overexpressed in many patients suffering from pituitary adenomas, primary epithelial neoplasias, and esophageal cancer. {ECO:0000269PubMed:9811450}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 56 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
56
[view]
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Protein-Protein |
51
[view]
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Protein-DNA |
5
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0003700
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sequence-specific DNA binding transcription factor activity
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GO:0004869
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cysteine-type endopeptidase inhibitor activity
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GO:0005515
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protein binding
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GO:0017124
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SH3 domain binding
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR006940
Securin sister-chromatid separation inhibitor
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PFAM |
PF04856
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
O95997
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PhosphoSite |
PhosphoSite-O95997
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TrEMBL |
Q6IAL9
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UniProt Splice Variant |
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Entrez Gene |
9232
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UniGene |
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RefSeq |
NP_001269311
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HUGO |
HGNC:9690
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OMIM |
604147
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CCDS |
CCDS4353
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HPRD |
04998
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IMGT |
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EMBL |
AB505430
AF075242
AF095287
AF167560
AF167561
AF167562
AF167563
AF167564
AJ223953
AK312209
BC101834
BC108894
BC108895
BC112071
BC113842
BC113896
BC128193
BC128194
CH471062
CR457135
CR541685
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GenPept |
AAC64409
AAD19335
AAF06995
AAI01835
AAI08895
AAI08896
AAI12072
AAI13843
AAI13897
AAI28194
AAI28195
BAG35142
BAH69082
CAA11683
CAG33416
CAG46486
EAW61551
EAW61552
EAW61553
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