InnateDB Protein
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IDBP-242799.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SLC29A1
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Protein Name
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solute carrier family 29 (nucleoside transporters), member 1
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Synonyms
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ENT1;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000377427
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InnateDB Gene
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IDBG-89061 (SLC29A1)
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Protein Structure
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Function |
Mediates both influx and efflux of nucleosides across the membrane (equilibrative transporter). It is sensitive (ES) to low concentrations of the inhibitor nitrobenzylmercaptopurine riboside (NBMPR) and is sodium-independent. It has a higher affinity for adenosine. Inhibited by dipyridamole and dilazep (anticancer chemotherapeutics drugs).
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Subcellular Localization |
Basolateral cell membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=Predominantly localized in the basolateral membrane in polarized MDCK cells.
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Disease Associations |
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Tissue Specificity |
Detected in erythrocytes (at protein level). Expressed in heart, brain, mammary gland, erythrocytes and placenta, and also in fetal liver and spleen. {ECO:0000269PubMed:12527552, ECO:0000269PubMed:23219802}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
3
[view]
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Protein-Protein |
3
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0005337
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nucleoside transmembrane transporter activity
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR002259
Equilibrative nucleoside transporter
IPR016196
Major facilitator superfamily domain, general substrate transporter
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PFAM |
PF01733
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PRINTS |
PR01130
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PIRSF |
PIRSF016379
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q99808
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PhosphoSite |
PhosphoSite-Q99808
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TrEMBL |
C8KHU2
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UniProt Splice Variant |
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Entrez Gene |
2030
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UniGene |
Hs.25450
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RefSeq |
NP_004946
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HUGO |
HGNC:11003
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OMIM |
602193
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CCDS |
CCDS4908
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HPRD |
03724
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IMGT |
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EMBL |
AB490708
AB490709
AF079117
AF190884
AF495730
AK090491
AK090615
AL139392
BC001382
BC008954
CH471081
U81375
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GenPept |
AAC51103
AAC62495
AAF02777
AAH01382
AAH08954
AAM11785
BAG52169
BAG52197
BAI39492
BAI39493
CAI20093
EAX04255
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