InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ST3GAL5

Summary

InnateDB Protein

IDBP-242874.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ST3GAL5

Protein Name

ST3 beta-galactoside alpha-2,3-sialyltransferase 5

Synonyms

SATI; SIAT9; SIATGM3S; ST3GalV;

Species

Homo sapiens

Ensembl Protein

ENSP00000377397

InnateDB Gene

IDBG-59513 (ST3GAL5)

Protein Structure

UniProt Annotation

Function

Catalyzes the formation of ganglioside GM3 (alpha-N- acetylneuraminyl-2,3-beta-D-galactosyl-1, 4-beta-D- glucosylceramide). {ECO:0000269PubMed:16934889}.

Subcellular Localization

Golgi apparatus membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.

Disease Associations

Amish infantile epilepsy syndrome (AIES) [MIM:609056]: An autosomal recessive, infantile-onset symptomatic epilepsy associated with developmental stagnation and blindness. {ECO:0000269PubMed:15502825}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Ubiquitous. High expression in brain, skeletal muscle, placenta, and testis.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004513	neolactotetraosylceramide alpha-2,3-sialyltransferase activity
GO:0008373	sialyltransferase activity
GO:0047291	lactosylceramide alpha-2,3-sialyltransferase activity

Biological Process

GO:0001574	ganglioside biosynthetic process
GO:0005975	carbohydrate metabolic process
GO:0006486	protein glycosylation
GO:0006688	glycosphingolipid biosynthetic process
GO:0097503	sialylation

Cellular Component

GO:0000139	Golgi membrane
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane
GO:0030173	integral component of Golgi membrane