Version 5.4
Homo sapiens Protein: HMG20A
Summary
InnateDB Protein IDBP-24313.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HMG20A
Protein Name high mobility group 20A
Synonyms HMGX1; HMGXB1;
Species Homo sapiens
Ensembl Protein ENSP00000336856
InnateDB Gene IDBG-24311 (HMG20A)
Protein Structure
UniProt Annotation
Function Plays a role in neuronal differentiation as chromatin- associated protein. Acts as inhibitor of HMG20B. Overcomes the repressive effects of the neuronal silencer REST and induces the activation of neuronal-specific genes. Involved in the recruitment of the histone methyltransferase KMT2A/MLL1 and consequent increased methylation of histone H3 lysine 4 (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000255PROSITE- ProRule:PRU00267}.
Disease Associations
Tissue Specificity Ubiquitous. {ECO:0000269PubMed:10773667}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 27 [view]
Protein-Protein 24 [view]
Protein-DNA 2 [view]
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
Biological Process
GO:0006325 chromatin organization
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR009071 High mobility group box domain
PFAM PF00505
PF09011
PRINTS
PIRSF
SMART SM00398
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9NP66
PhosphoSite PhosphoSite-Q9NP66
TrEMBL H0YNS8
UniProt Splice Variant
Entrez Gene 10363
UniGene Hs.737244
RefSeq XP_005254180
HUGO HGNC:5001
OMIM 605534
CCDS CCDS10295
HPRD 16116
IMGT
EMBL AC090984 AF146222 AK001601 AK223100 AK297449 AK316281 AL355736 AL355737 BC021959 BT006716 CH471136
GenPept AAF66706 AAH21959 AAP35362 BAA91782 BAD96820 BAG59873 BAH14652 CAB90815 CAB90816 EAW99201 EAW99202 EAW99203

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca