InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SRPK2

Summary

InnateDB Protein

IDBP-243189.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SRPK2

Protein Name

SRSF protein kinase 2

Synonyms

SFRSK2;

Species

Homo sapiens

Ensembl Protein

ENSP00000377262

InnateDB Gene

IDBG-34933 (SRPK2)

Protein Structure

UniProt Annotation

Function

Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Promotes neuronal apoptosis by up-regulating cyclin-D1 (CCND1) expression. This is done by the phosphorylation of SRSF2, leading to the suppression of p53/TP53 phosphorylation thereby relieving the repressive effect of p53/TP53 on cyclin-D1 (CCND1) expression. Phosphorylates ACIN1, and redistributes it from the nuclear speckles to the nucleoplasm, resulting in cyclin A1 but not cyclin A2 up- regulation. Plays an essential role in spliceosomal B complex formation via the phosphorylation of DDX23/PRP28. Can mediate hepatitis B virus (HBV) core protein phosphorylation. Plays a negative role in the regulation of HBV replication through a mechanism not involving the phosphorylation of the core protein but by reducing the packaging efficiency of the pregenomic RNA (pgRNA) without affecting the formation of the viral core particles. {ECO:0000269PubMed:12134018, ECO:0000269PubMed:16122776, ECO:0000269PubMed:18425142, ECO:0000269PubMed:18559500, ECO:0000269PubMed:19592491, ECO:0000269PubMed:21056976, ECO:0000269PubMed:21157427, ECO:0000269PubMed:9472028}.

Subcellular Localization

Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm. KAT5/TIP60 inhibits its nuclear translocation. Phosphorylation at Thr-492 by PKB/AKT1 promotes nuclear translocation.

Disease Associations

Tissue Specificity

Highly expressed in brain, moderately expressed in heart and skeletal muscle and at low levels in lung, liver, and kidney. {ECO:0000269PubMed:9472028}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 287 experimentally validated interaction(s) in this database.

Experimentally validated
Total	287 [view]
Protein-Protein	287 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0044822	poly(A) RNA binding
GO:0071889	14-3-3 protein binding

Biological Process

GO:0000245	spliceosomal complex assembly
GO:0001525	angiogenesis
GO:0006468	protein phosphorylation
GO:0008284	positive regulation of cell proliferation
GO:0008380	RNA splicing
GO:0010628	positive regulation of gene expression
GO:0030154	cell differentiation
GO:0035063	nuclear speck organization
GO:0035556	intracellular signal transduction
GO:0043525	positive regulation of neuron apoptotic process
GO:0045070	positive regulation of viral genome replication
GO:0045071	negative regulation of viral genome replication
GO:0045087	innate immune response
GO:0045787	positive regulation of cell cycle
GO:0048024	regulation of mRNA splicing, via spliceosome

Cellular Component

GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt