Version 5.4
Homo sapiens Protein: LIPT1
Summary
InnateDB Protein IDBP-243546.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LIPT1
Protein Name lipoyltransferase 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000377114
InnateDB Gene IDBG-63192 (LIPT1)
Protein Structure
UniProt Annotation
Function Catalyzes the transfer of the lipoyl group from lipoyl- AMP to the specific lysine residue of lipoyl domains of lipoate- dependent enzymes. {ECO:0000250}.
Subcellular Localization Mitochondrion.
Disease Associations
Tissue Specificity Highly expressed in skeletal muscle and heart, moderately in kidney and pancreas, and detected at lower levels in liver, brain, placenta and lung. {ECO:0000269PubMed:10103005}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0016740 transferase activity
GO:0016746 transferase activity, transferring acyl groups
Biological Process
GO:0006464 cellular protein modification process
GO:0006629 lipid metabolic process
GO:0009249 protein lipoylation
Cellular Component
GO:0005739 mitochondrion
Protein Structure and Domains
PDB ID
InterPro IPR004143 Biotin/lipoate A/B protein ligase
IPR004562 Lipoyltransferase/lipoate-protein ligase
PFAM PF03099
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9Y234
PhosphoSite PhosphoSite-Q9Y234
TrEMBL C9JW10
UniProt Splice Variant
Entrez Gene 51601
UniGene Hs.739177
RefSeq NP_660200
HUGO HGNC:29569
OMIM 610284
CCDS CCDS2039
HPRD 17282
IMGT
EMBL AB017566 AB017567 AC092587 BC007001 BC009772 BC070145 CH471127
GenPept AAH07001 AAH09772 AAH70145 AAX88927 BAA76367 BAA76368 EAX01877

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca