InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CAV1

Summary

InnateDB Protein

IDBP-243552.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CAV1

Protein Name

caveolin 1, caveolae protein, 22kDa

Synonyms

BSCL3; CGL3; LCCNS; MSTP085; PPH3; VIP21;

Species

Homo sapiens

Ensembl Protein

ENSP00000377110

InnateDB Gene

IDBG-37314 (CAV1)

Protein Structure

UniProt Annotation

Function

May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)- mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3- dependent manner. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway. {ECO:0000250, ECO:0000269PubMed:11751885, ECO:0000269PubMed:17287217}.

Subcellular Localization

Golgi apparatus membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein. Membrane, caveola; Peripheral membrane protein. Membrane raft. Note=Colocalized with DPP4 in membrane rafts. Potential hairpin- like structure in the membrane. Membrane protein of caveolae.

Disease Associations

Congenital generalized lipodystrophy 3 (CGL3) [MIM:612526]: An autosomal recessive disorder characterized by a near complete absence of adipose tissue, extreme insulin resistance, hypertriglyceridemia, hepatic steatosis and early onset of diabetes. {ECO:0000269PubMed:18211975}. Note=The disease is caused by mutations affecting the gene represented in this entry.Pulmonary hypertension, primary, 3 (PPH3) [MIM:615343]: A rare disorder characterized by plexiform lesions of proliferating endothelial cells in pulmonary arterioles. The lesions lead to elevated pulmonary arterial pression, right ventricular failure, and death. The disease can occur from infancy throughout life and it has a mean age at onset of 36 years. Penetrance is reduced. Although familial pulmonary hypertension is rare, cases secondary to known etiologies are more common and include those associated with the appetite-suppressant drugs. {ECO:0000269PubMed:22474227}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Expressed in muscle and lung, less so in liver, brain and kidney.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 213 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.

Experimentally validated
Total	213 [view]
Protein-Protein	208 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	1 [view]
DNA-RNA	0

Predicted by orthology
Total	17 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005113	patched binding
GO:0005198	structural molecule activity
GO:0005515	protein binding
GO:0015485	cholesterol binding
GO:0016504	peptidase activator activity
GO:0019899	enzyme binding
GO:0032947	protein complex scaffold
GO:0050998	nitric-oxide synthase binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0000188	inactivation of MAPK activity
GO:0001570	vasculogenesis
GO:0001666	response to hypoxia
GO:0001937	negative regulation of endothelial cell proliferation
GO:0006641	triglyceride metabolic process
GO:0006816	calcium ion transport
GO:0006874	cellular calcium ion homeostasis
GO:0006940	regulation of smooth muscle contraction
GO:0007519	skeletal muscle tissue development
GO:0007596	blood coagulation
GO:0008104	protein localization
GO:0009267	cellular response to starvation
GO:0010524	positive regulation of calcium ion transport into cytosol
GO:0016032	viral process
GO:0016050	vesicle organization
GO:0019217	regulation of fatty acid metabolic process
GO:0019915	lipid storage
GO:0030193	regulation of blood coagulation
GO:0030301	cholesterol transport
GO:0030514	negative regulation of BMP signaling pathway
GO:0030857	negative regulation of epithelial cell differentiation
GO:0030879	mammary gland development
GO:0031295	T cell costimulation
GO:0031397	negative regulation of protein ubiquitination
GO:0032091	negative regulation of protein binding
GO:0032507	maintenance of protein location in cell
GO:0032570	response to progesterone
GO:0033137	negative regulation of peptidyl-serine phosphorylation
GO:0033138	positive regulation of peptidyl-serine phosphorylation
GO:0033484	nitric oxide homeostasis
GO:0042632	cholesterol homeostasis
GO:0043409	negative regulation of MAPK cascade
GO:0043627	response to estrogen
GO:0044281	small molecule metabolic process
GO:0045019	negative regulation of nitric oxide biosynthetic process
GO:0045087	innate immune response (InnateDB)
GO:0045907	positive regulation of vasoconstriction
GO:0046209	nitric oxide metabolic process
GO:0046426	negative regulation of JAK-STAT cascade
GO:0048550	negative regulation of pinocytosis
GO:0048554	positive regulation of metalloenzyme activity
GO:0050900	leukocyte migration
GO:0050999	regulation of nitric-oxide synthase activity
GO:0051260	protein homooligomerization
GO:0051480	cytosolic calcium ion homeostasis
GO:0051592	response to calcium ion
GO:0051899	membrane depolarization
GO:0052547	regulation of peptidase activity
GO:0055074	calcium ion homeostasis
GO:0060056	mammary gland involution
GO:0070836	caveola assembly
GO:0071455	cellular response to hyperoxia
GO:0072584	caveolin-mediated endocytosis
GO:0090090	negative regulation of canonical Wnt signaling pathway
GO:0090263	positive regulation of canonical Wnt signaling pathway
GO:0097190	apoptotic signaling pathway
GO:2000286	receptor internalization involved in canonical Wnt receptor signaling pathway
GO:2000811	negative regulation of anoikis
GO:2001238	positive regulation of extrinsic apoptotic signaling pathway
GO:2001244	positive regulation of intrinsic apoptotic signaling pathway

Cellular Component

GO:0000139	Golgi membrane
GO:0005622	intracellular
GO:0005768	endosome
GO:0005783	endoplasmic reticulum
GO:0005811	lipid particle
GO:0005886	plasma membrane
GO:0005901	caveola
GO:0016323	basolateral plasma membrane
GO:0016324	apical plasma membrane
GO:0030666	endocytic vesicle membrane
GO:0031410	cytoplasmic vesicle
GO:0043234	protein complex
GO:0045121	membrane raft
GO:0048471	perinuclear region of cytoplasm