InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GOSR2

Summary

InnateDB Protein

IDBP-243594.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GOSR2

Protein Name

golgi SNAP receptor complex member 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000377101

InnateDB Gene

IDBG-55751 (GOSR2)

Protein Structure

UniProt Annotation

Function

Involved in transport of proteins from the cis/medial- Golgi to the trans-Golgi network.

Subcellular Localization

Golgi apparatus, cis-Golgi network membrane {ECO:0000250}; Single-pass type IV membrane protein {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}. Note=Concentrated most in the intermediate compartment/cis-Golgi network and the cis-Golgi cisternae 1 and 2. Greatly reduced in concentration at the trans end of the Golgi apparatus (By similarity). {ECO:0000250}.

Disease Associations

Epilepsy, progressive myoclonic 6 (EPM6) [MIM:614018]: A neurologic disorder characterized by onset of ataxia in the first years of life, followed by action myoclonus and seizures later in childhood, and loss of independent ambulation in the second decade. Cognition is not usually affected, although mild memory difficulties may occur in the third decade. {ECO:0000269PubMed:21549339}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.

Experimentally validated
Total	10 [view]
Protein-Protein	9 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005215	transporter activity

Biological Process

GO:0006888	ER to Golgi vesicle-mediated transport
GO:0006987	activation of signaling protein activity involved in unfolded protein response
GO:0015031	protein transport
GO:0016192	vesicle-mediated transport
GO:0030968	endoplasmic reticulum unfolded protein response
GO:0044267	cellular protein metabolic process
GO:0061025	membrane fusion