InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: EREG

Summary

InnateDB Protein

IDBP-24372.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EREG

Protein Name

epiregulin

Synonyms

ER;

Species

Homo sapiens

Ensembl Protein

ENSP00000244869

InnateDB Gene

IDBG-24370 (EREG)

Protein Structure

UniProt Annotation

Function

Ligand of the EGF receptor/EGFR and ERBB4. May be a mediator of localized cell proliferation. As a mitogen it may stimulate cell proliferation and/or angiogenesis. {ECO:0000269PubMed:9419975}.

Subcellular Localization

Epiregulin: Secreted, extracellular space.Proepiregulin: Cell membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

In normal adults, expressed predominantly in the placenta and peripheral blood leukocytes. High levels were detected in carcinomas of the bladder, lung, kidney and colon.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005154	epidermal growth factor receptor binding
GO:0005515	protein binding
GO:0008083	growth factor activity

Biological Process

GO:0001525	angiogenesis
GO:0001550	ovarian cumulus expansion
GO:0001556	oocyte maturation
GO:0001819	positive regulation of cytokine production
GO:0007143	female meiotic division
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0007267	cell-cell signaling
GO:0008284	positive regulation of cell proliferation
GO:0008285	negative regulation of cell proliferation
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0009299	mRNA transcription
GO:0009653	anatomical structure morphogenesis
GO:0009887	organ morphogenesis
GO:0019221	cytokine-mediated signaling pathway
GO:0030216	keratinocyte differentiation
GO:0030728	ovulation
GO:0038095	Fc-epsilon receptor signaling pathway
GO:0042060	wound healing
GO:0042108	positive regulation of cytokine biosynthetic process
GO:0042327	positive regulation of phosphorylation
GO:0042700	luteinizing hormone signaling pathway
GO:0043434	response to peptide hormone
GO:0043616	keratinocyte proliferation
GO:0045087	innate immune response
GO:0045089	positive regulation of innate immune response
GO:0045410	positive regulation of interleukin-6 biosynthetic process
GO:0045740	positive regulation of DNA replication
GO:0045741	positive regulation of epidermal growth factor-activated receptor activity
GO:0045840	positive regulation of mitosis
GO:0045860	positive regulation of protein kinase activity
GO:0045892	negative regulation of transcription, DNA-templated
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0048015	phosphatidylinositol-mediated signaling
GO:0048146	positive regulation of fibroblast proliferation
GO:0048160	primary follicle stage
GO:0048661	positive regulation of smooth muscle cell proliferation
GO:0050680	negative regulation of epithelial cell proliferation
GO:0051151	negative regulation of smooth muscle cell differentiation
GO:0051781	positive regulation of cell division