InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NCK2

Summary

InnateDB Protein

IDBP-243807.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NCK2

Protein Name

NCK adaptor protein 2

Synonyms

GRB4; NCKbeta;

Species

Homo sapiens

Ensembl Protein

ENSP00000377018

InnateDB Gene

IDBG-64634 (NCK2)

Protein Structure

UniProt Annotation

Function

Adapter protein which associates with tyrosine- phosphorylated growth factor receptors or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in ELK1- dependent transcriptional activation in response to activated Ras signaling. {ECO:0000269PubMed:10026169, ECO:0000269PubMed:16835242}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:16835242}. Endoplasmic reticulum {ECO:0000269PubMed:16835242}.

Disease Associations

Tissue Specificity

Ubiquitous.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 79 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	79 [view]
Protein-Protein	79 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008093	cytoskeletal adaptor activity
GO:0030159	receptor signaling complex scaffold activity

Biological Process

GO:0006417	regulation of translation
GO:0007165	signal transduction
GO:0007172	signal complex assembly
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0007176	regulation of epidermal growth factor-activated receptor activity
GO:0007411	axon guidance
GO:0008285	negative regulation of cell proliferation
GO:0030838	positive regulation of actin filament polymerization
GO:0042102	positive regulation of T cell proliferation
GO:0042110	T cell activation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter