Homo sapiens Protein: DENND2C
Summary
InnateDB Protein IDBP-243944.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DENND2C
Protein Name DENN/MADD domain containing 2C
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000376957
InnateDB Gene IDBG-101294 (DENND2C)
Protein Structure
UniProt Annotation
Function Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP- bound form. {ECO:0000269PubMed:20937701}.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0017112 Rab guanyl-nucleotide exchange factor activity
Biological Process
GO:0032851 positive regulation of Rab GTPase activity
Cellular Component
Protein Structure and Domains
PDB ID
InterPro IPR001194 DENN domain
IPR005112 dDENN domain
IPR005113 uDENN domain
PFAM PF02141
PF03455
PF03456
PRINTS
PIRSF
SMART SM00799
SM00801
SM00800
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q68D51
PhosphoSite PhosphoSite-Q68D51
TrEMBL
UniProt Splice Variant
Entrez Gene 163259
UniGene Hs.597521
RefSeq NP_940861
HUGO HGNC:24748
OMIM
CCDS CCDS875
HPRD 13425
IMGT
EMBL AL133382 BC063894 BX647950 CR749576
GenPept CAH18369 CAI19301 CAM27633