InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MRE11A

Summary

InnateDB Protein

IDBP-244013.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MRE11A

Protein Name

MRE11 meiotic recombination 11 homolog A (S. cerevisiae)

Synonyms

ATLD; HNGS1; MRE11; MRE11B;

Species

Homo sapiens

Ensembl Protein

ENSP00000376933

InnateDB Gene

IDBG-68191 (MRE11A)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 125 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	126 [view]
Protein-Protein	119 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	4 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004519	endonuclease activity
GO:0004527	exonuclease activity
GO:0016787	hydrolase activity
GO:0030145	manganese ion binding

Biological Process

GO:0006259	DNA metabolic process
GO:0006302	double-strand break repair
GO:0007126	meiotic nuclear division
GO:0090305	nucleic acid phosphodiester bond hydrolysis

Cellular Component

GO:0005634

nucleus

Protein Structure and Domains

PDB ID

InterPro

IPR003701 DNA repair protein Mre11
IPR004843 Calcineurin-like phosphoesterase domain, apaH type
IPR007281 Mre11, DNA-binding
IPR029052 Metallo-dependent phosphatase-like

PFAM

PF00149
PF04152

PRINTS

PIRSF

PIRSF000882

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite