InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SERPINA3

Summary

InnateDB Protein

IDBP-244346.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SERPINA3

Protein Name

serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000376793

InnateDB Gene

IDBG-18406 (SERPINA3)

Protein Structure

UniProt Annotation

Function

Although its physiological function is unclear, it can inhibit neutrophil cathepsin G and mast cell chymase, both of which can convert angiotensin-1 to the active angiotensin-2. {ECO:0000269PubMed:2404007}.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Plasma. Synthesized in the liver. Like the related alpha-1-antitrypsin, its concentration increases in the acute phase of inflammation or infection. Found in the amyloid plaques from the hippocampus of Alzheimer disease brains. {ECO:0000269PubMed:3257719, ECO:0000269PubMed:9880565}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.

Experimentally validated
Total	16 [view]
Protein-Protein	16 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0004867	serine-type endopeptidase inhibitor activity
GO:0005515	protein binding

Biological Process

GO:0006953	acute-phase response
GO:0006954	inflammatory response
GO:0010951	negative regulation of endopeptidase activity
GO:0019216	regulation of lipid metabolic process
GO:0030162	regulation of proteolysis
GO:0030277	maintenance of gastrointestinal epithelium

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005622	intracellular
GO:0005634	nucleus
GO:0070062	extracellular vesicular exosome
GO:0072562	blood microparticle