Version 5.4
Homo sapiens Protein: SPIRE2
Summary
InnateDB Protein IDBP-244389.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SPIRE2
Protein Name spire homolog 2 (Drosophila)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000376782
InnateDB Gene IDBG-48448 (SPIRE2)
Protein Structure
UniProt Annotation
Function Acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament. Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport. Required for asymmetric spindle positioning and asymmetric cell division during meiosis. Required for normal formation of the cleavage furrow and for polar body extrusion during female germ cell meiosis. {ECO:0000269PubMed:21620703}.
Subcellular Localization Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasmic vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Detected at the cleavage furrow during asymmetric oocyte division and polar body extrusion. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
Biological Process
GO:0015031 protein transport
GO:0016192 vesicle-mediated transport
GO:0030036 actin cytoskeleton organization
GO:0036089 cleavage furrow formation
GO:0040038 polar body extrusion after meiotic divisions
GO:0046907 intracellular transport
GO:0051295 establishment of meiotic spindle localization
GO:0070649 formin-nucleated actin cable assembly
Cellular Component
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0005938 cell cortex
GO:0030659 cytoplasmic vesicle membrane
GO:0032154 cleavage furrow
GO:0048471 perinuclear region of cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR011011 Zinc finger, FYVE/PHD-type
IPR011019 KIND
PFAM
PRINTS
PIRSF
SMART SM00750
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8WWL2
PhosphoSite PhosphoSite-Q8WWL2
TrEMBL
UniProt Splice Variant
Entrez Gene 84501
UniGene Hs.734199
RefSeq XP_006721367
HUGO HGNC:30623
OMIM 609217
CCDS
HPRD 18099
IMGT
EMBL AB058735 AJ422077 AL834408 BC063706 BC111030 BC139732
GenPept AAH63706 AAI11031 AAI39733 BAB47461 CAD19439 CAD39070

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

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Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca