InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CLTC

Summary

InnateDB Protein

IDBP-244413.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CLTC

Protein Name

clathrin, heavy chain (Hc)

Synonyms

CHC; CHC17; CLH-17; CLTCL2; Hc;

Species

Homo sapiens

Ensembl Protein

ENSP00000376763

InnateDB Gene

IDBG-61767 (CLTC)

Protein Structure

UniProt Annotation

Function

Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network.

Subcellular Localization

Cytoplasmic vesicle membrane {ECO:0000269PubMed:17081065}; Peripheral membrane protein {ECO:0000269PubMed:17081065}; Cytoplasmic side {ECO:0000269PubMed:17081065}. Membrane, coated pit {ECO:0000269PubMed:17081065}; Peripheral membrane protein {ECO:0000269PubMed:17081065}; Cytoplasmic side {ECO:0000269PubMed:17081065}. Melanosome {ECO:0000269PubMed:17081065}. Note=Cytoplasmic face of coated pits and vesicles. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 167 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	167 [view]
Protein-Protein	167 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003725	double-stranded RNA binding
GO:0005198	structural molecule activity
GO:0005488	binding
GO:0005515	protein binding
GO:0019901	protein kinase binding
GO:0032051	clathrin light chain binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0001649	osteoblast differentiation
GO:0006886	intracellular protein transport
GO:0006892	post-Golgi vesicle-mediated transport
GO:0006898	receptor-mediated endocytosis
GO:0007067	mitotic nuclear division
GO:0016192	vesicle-mediated transport
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0031623	receptor internalization
GO:0033572	transferrin transport
GO:0045087	innate immune response (InnateDB)
GO:0061024	membrane organization
GO:1900126	negative regulation of hyaluronan biosynthetic process

Cellular Component

GO:0005819	spindle
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0030118	clathrin coat
GO:0030130	clathrin coat of trans-Golgi network vesicle
GO:0030132	clathrin coat of coated pit
GO:0030136	clathrin-coated vesicle
GO:0030669	clathrin-coated endocytic vesicle membrane
GO:0032588	trans-Golgi network membrane
GO:0042470	melanosome
GO:0043234	protein complex
GO:0070062	extracellular vesicular exosome
GO:0071439	clathrin complex

Protein Structure and Domains

PDB ID

InterPro

IPR000547 Clathrin, heavy chain/VPS, 7-fold repeat
IPR001473 Clathrin, heavy chain, propeller, N-terminal
IPR015348 Clathrin, heavy chain, linker, core motif
IPR016024 Armadillo-type fold
IPR016341 Clathrin, heavy chain
IPR022365 Clathrin, heavy chain, propeller repeat

PFAM

PF00637
PF09268
PF01394

PRINTS

PIRSF

PIRSF002290

SMART

SM00299

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt