InnateDB Protein
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IDBP-244787.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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RGS10
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Protein Name
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regulator of G-protein signaling 10
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000376605
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InnateDB Gene
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IDBG-91166 (RGS10)
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Protein Structure
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Function |
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Associates specifically with the activated forms of the G protein subunits G(i)-alpha and G(z)- alpha but fails to interact with the structurally and functionally distinct G(s)-alpha subunit. Activity on G(z)-alpha is inhibited by palmitoylation of the G-protein.
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Subcellular Localization |
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
12
[view]
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Protein-Protein |
12
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0005096
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GTPase activator activity
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Biological Process |
GO:0008277
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regulation of G-protein coupled receptor protein signaling pathway
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GO:0038032
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termination of G-protein coupled receptor signaling pathway
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GO:0043547
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positive regulation of GTPase activity
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Cellular Component |
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PDB ID |
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InterPro |
IPR000342
Regulator of G protein signalling domain
IPR016137
Regulator of G protein signalling superfamily
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PFAM |
PF00615
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PRINTS |
PR01301
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PIRSF |
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SMART |
SM00315
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TIGRFAMs |
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Modification |
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SwissProt |
O43665
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PhosphoSite |
PhosphoSite-O43665
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
6001
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UniGene |
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RefSeq |
NP_002916
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HUGO |
HGNC:9992
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OMIM |
602856
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CCDS |
CCDS41572
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HPRD |
04172
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IMGT |
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EMBL |
AC012468
AF045229
AF368902
AF493934
AK290773
AL355273
BC009361
CH471066
CR457008
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GenPept |
AAC03783
AAH09361
AAK52979
AAM12648
BAF83462
CAG33289
CAI16486
CAI16488
EAW49389
EAW49390
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