InnateDB Protein
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IDBP-244828.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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ORC3
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Protein Name
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origin recognition complex, subunit 3
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Synonyms
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LAT; LATHEO; ORC3L;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000376586
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InnateDB Gene
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IDBG-94195 (ORC3)
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Protein Structure
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Function |
Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre- replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3. {ECO:0000269PubMed:22427655}.
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Subcellular Localization |
Nucleus.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 47 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
47
[view]
|
Protein-Protein |
44
[view]
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Protein-DNA |
3
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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|
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR020795
Origin recognition complex, subunit 3
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PFAM |
PF07034
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9UBD5
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PhosphoSite |
PhosphoSite-Q9UBD5
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TrEMBL |
U3KQL3
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UniProt Splice Variant |
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Entrez Gene |
23595
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UniGene |
Hs.735758
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RefSeq |
NP_036513
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HUGO |
HGNC:8489
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OMIM |
604972
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CCDS |
CCDS43486
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HPRD |
05398
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IMGT |
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EMBL |
AF093535
AF125507
AF135044
AK222795
AK303195
AK315911
AL080116
AL133211
AL451126
AY623113
BC035494
BC047689
U50950
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GenPept |
AAA96313
AAD18057
AAD30282
AAD40220
AAH35494
AAH47689
AAT38109
BAD96515
BAG64287
BAH14282
CAB45715
CAI10900
CAI21539
CAM13063
CAM28255
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